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Section: Partnerships and Cooperations
International Initiatives
Inria Associate Teams
QUANTISS , with BMBF
International Partner (Institution - Laboratory - Researcher):
See also: http://www.msysbio.com/ea
The scientific achievements addressed tissue organisation processes such as tissue regeneration, degeneration and growth. Our main contribution was the development of concepts, a process chain, and software suite to permit quantitative simulations of tissue organisation processes on histological scales. Our main applications were multiple projects on liver, lung cancer and mesenchymal stem cell differentiation. The results of the main projects for 2012 have briefly been summarised the results section (liver regeneration, multiscale liver modelling, blood flow modelling, software generation CellSys, etc. most based on the grant projects LUNGSYS and Virtual Liver network).
ECOS-CONICYT
B. Perthame and K. Vilches take part in the Franco-Chilean project `Functional analysis, asymptotics and dynamics of fronts' headed by J. Dolbeault (University Paris-Dauphine) funded by ECOS-CONICYT.
EuroMed 3+3
M3CD, Mathematical Models and Methods in Cell Dynamics, a transmediterranean EuroMed3+3 program, has begun in January 2012 for 2 [+ 2: renewal] years, under the coordination of J. Clairambault. It associates 2 Inria teams: Bang and Dracula (Mostafa Adimy, Lyon) with the IAC-CNR in Rome (Roberto Natalini), the LMDP team in Marrakech (Hassan Hbid) and the MoMinBi team at Institut Pasteur, Tunis (Slimane BenMiled) to work on the general theme “Mathematical Models and Methods in Cell Dynamics”. It has fostered visits of students (in particular to Paris and Lyon, for Y. Bourfia, PhD student at Marrakech and UPMC, who works under the supervision of H. Hbid, M. Adimy and J. Clairambault) and researchers, participation in the international SM2A conference in Marrakech (June 2012, url http://sm2a-2012.ucam.ac.ma/en/ ), and a M3CD 2-day workshop in Tunis (Institut Pasteur, November 2012, (url http://euromedbiomaths.org/atelier-M3CD-Tunis/ )) organised by Amira Kebir (MoMinBi).
Inria International Partners
German Research Ministry (BMBF) funded project on the systems biology of lung cancer
The major aim is to better understand the early metastasis formation and invasion of lung cancer, including therapeutical options. Data on all levels ranging from intracellular up to organ level will be used to establish successively an integrated multiscale model of cellular and migration decisions in lung cancer. A particular focus will be on dissecting how cellular organisation and communication in spheroid cultures and co-cultures of lung cancer cell lines with selected endothelial cells affects information processing and the proliferation and migration decisions downstream. To reveal the inhomogeneous spatio-temporal organisation in these tumour growth models, specific probes for medical imaging, quantify extracellular cytokine concentrations will be used, and the effects of pharmacological inhibitors be monitored. By data and model integration, parameters should be identified that critically determine early spread and facilitate to predict possibilities for improved therapeutic options.
The project coordinator is Ursula Klingmueller, German Cancer Research Centre (DKFZ), Heidelberg ()
German Research Ministry (BMBF) funded project on the systems biology of liver (Virtual Liver Network)
The aim of the VLN project is to set up multiscale models of liver. The Virtual Liver will be a dynamic model that represents, rather than fully replicates, human liver physiology morphology and function, integrating quantitive data from all levels of organisation. Our part ranges from the intracellular up to the level of groups of liver lobules. A liver lobule is the basic repetitive functional unit of liver. Applications are explained in the text. The networks has 69 Principle Investigators organised in about 10 work packages, each of which have a number of sub-projects.
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